Targeting the IGF-1R signaling and mechanisms for epigenetic gene silencing in human multiple myeloma

Helena Jernberg-Wiklund, Kenneth Nilsson
2012 Upsala Journal of Medical Sciences  
Multiple myeloma (MM) is a B cell malignancy characterized by the expansion of clonal plasmablast/plasma cells within the bone-marrow. It is well established that the bone-marrow microenvironment has a pivotal role in providing critical cytokines and cell-cell interactions to support the growth and survival of the MM tumor clone. The pathogenesis of MM is, however, only fragmentarily understood. Detailed genomic analysis reveals a heterogeneous and complex pattern of structural and numerical
more » ... omosomal aberrations. In this review we will discuss some of the recent results on the functional role and potential clinical use of the IGF-1R, one of the major mediators of growth and survival for MM. We will also describe some of our results on epigenetic gene silencing in MM, as it may indeed constitute a novel basis for the understanding of tumor initiation and maintenance in MM and thus may change the current view on treatment strategies for MM.
doi:10.3109/03009734.2012.659293 pmid:22348393 pmcid:PMC3339548 fatcat:24pr3r6kbvcdhaynptmtpggaeq