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Targeting the IGF-1R signaling and mechanisms for epigenetic gene silencing in human multiple myeloma
2012
Upsala Journal of Medical Sciences
Multiple myeloma (MM) is a B cell malignancy characterized by the expansion of clonal plasmablast/plasma cells within the bone-marrow. It is well established that the bone-marrow microenvironment has a pivotal role in providing critical cytokines and cell-cell interactions to support the growth and survival of the MM tumor clone. The pathogenesis of MM is, however, only fragmentarily understood. Detailed genomic analysis reveals a heterogeneous and complex pattern of structural and numerical
doi:10.3109/03009734.2012.659293
pmid:22348393
pmcid:PMC3339548
fatcat:24pr3r6kbvcdhaynptmtpggaeq