Chondroitin, Dermatan, Heparan, and Keratan Sulfate: Structure and Functions [chapter]

Emiliano Bedini, Maria Michela Corsaro, Alfonso Fernández-Mayoralas, Alfonso Iadonisi
2019 Biologically-Inspired Systems  
Sulfated glycosaminoglycans (heparan sulfate, chondroitin sulfate, dermatan sulfate, and keratan sulfate) are a family of complex polysaccharides ubiquitously, but not exclusively, distributed among mammals, found both in extracellular matrices and on cell surfaces. They play key roles in a myriad of physiological and pathological processes, including, among others, angiogenesis, cancer, immunity, and infectious diseases. Here the main issues concerning their chemical structure, biosynthesis,
more » ... re, biosynthesis, extraction, and purification from natural sources, structural characterization, as well as their most important biological functions are discussed.
doi:10.1007/978-3-030-12919-4_5 fatcat:neyip4ensnelnoa5xsoawvf7n4