Interstitial beta-ablation: in search of the Holy Grail

Lucio Fumi
2018 Journal of Liver Research Disorders & Therapy  
Submit Manuscript | Progression Free Survival and Overall Survival. As the necrotising effect is achieved with beta-emission from a number of different radio-active isotopes delivered directly into the tumoral lesion, rather than through the traditional intra-arterial route, this treatment is often called "Interstitial Beta-Ablation". The definition "interstitial" is not totally correct, however: a needle large enough to deliver the radio-active isotopes and their
more » ... opes and their vehicle will inevitably cause cellular damage, both in the tumoral lesion and in the healthy parenchyma it has to cross to reach the lesion; in other words, it is not just the interstitial space that is the target of the injection. Alternative definitions have been used, such as "parenchymal" and "intratumoral", even if this latter definition is often used also for intra-arterial approaches. Organs other than the liver can be targeted: pancreas, kidney, lung and breast have been considered. The percutaneous route, furthermore, is not the only one used: intra-operatory and peri-endoscopic routes are being investigated, depending on the target organ. Some of the isotopes listed above are pure beta-emitters (Yttrium 90, Phosphorus 32), other (Holmium 166, Rhenium 188) have also a low-energy level of gamma emission. This can be extremely useful for J Liver Res Disord Ther. 2018;4(2):94-95 94
doi:10.15406/jlrdt.2018.04.00108 fatcat:gyikrhegfzajbdalehpmxmanyq