Breast cancer is the most common malignancy in women in the world. Metastatic breast cancer (MBC) still remains incurable, and despite the many advances that have been achieved, the prognosis for those patients remains poor. Palliative RT is an efficacious treatment for ulcerative breast cancer with minimal toxicity. Aim of work: The aim of this study to retrospectively evaluate the outcomes of the 20Gy in 5 fractions and 30Gy in 10 fractions regimes in patients with advanced or metastatic

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... t cancer at Zagazig University. Patients and methods: This is a retrospective study on 20 patients with advanced breast cancer treated by palliative hypofraction radiotherapy at Clinical Oncology and Nuclear Medicine Department in Zagazig University Hospitals last 5 years. Data were collected retrospectively from records in last 5 years. Results: Majority of our studied groups were positive regard ER and PR, HER 2 were positive in only 12.5% and 33.3% respectively and Ki 67 were not done in majority of both groups. The local progression free survival (PFS) was not statistically significant between the two groups. The 30 Gy group received a higher equivalent dose compared to the 20 Gy group. ER status was a significant prognostic factor. This could be due to the added benefit of hormonal treatment in local control. Conclusion: The 20 Gy regime is a reasonable alternative for local control to the 30Gy regime in patients with locally advanced breast cancer.