Joint modelling of longitudinal 3MS scores and the risk of mortality among cognitively impaired individuals

Chris B. Guure, Noor Akma Ibrahim, Mohd Bakri Adam, Salmiah Md Said, Stephen D Ginsberg
2017 PLoS ONE  
Modified Mini-Mental State Examination (3MS) is an instrument administered by trained personnel to examine levels of participants' cognitive function. However, the association between changes in scores over time and the risk of death (mortality) is not known. The aims of this study are to examine the association between 3MS scores and mortality via cognitive impairment among older women and to determine individuals' risk of changes in scores to better predict their survival and mortality rates.
more » ... Methods We propose a Bayesian joint modelling approach to determine mortality due to cognitive impairment via repeated measures of 3MS scores trajectories over a 21-year follow-up period. Data for this study are taken from the Osteoporotic Fracture longitudinal study among women aged 65+ which started in 1986-88. OPEN ACCESS Citation: Guure CB, Ibrahim NA, Adam MB, Said SM (2017) Joint modelling of longitudinal 3MS scores and the risk of mortality among cognitively impaired individuals. PLoS ONE 12(8): e0182873.
doi:10.1371/journal.pone.0182873 pmid:28813458 pmcid:PMC5558951 fatcat:4bwizz3yonfghc2ob76m4utrde