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Acanthocytic red blood cells (RBCs) are a peculiar diagnostic feature of chorea-acanthocytosis (ChAc), a rare autosomal recessive neurodegenerative disorder. Although recent years have witnessed some progress in the molecular characterization of ChAc, the mechanism(s) responsible for generation of acanthocytes in ChAc is largely unknown. As the membrane protein composition of ChAc RBCs is similar to that of normal RBCs, we evaluated the tyrosine-(Tyr)-phosphorylation profile of RBCs usingdoi:10.5167/uzh-50706 fatcat:txdrm4e5jvechhe6wp33z2npfy