Toward the dynamic interactome: it's about time

T. M. Przytycka, M. Singh, D. K. Slonim
2010 Briefings in Bioinformatics  
Dynamic molecular interactions play a central role in regulating the functioning of cells and organisms. The availability of experimentally determined large-scale cellular networks, along with other high-throughput experimental data sets that provide snapshots of biological systems at different times and conditions, is increasingly helpful in elucidating interaction dynamics. Here we review the beginnings of a new subfield within computational biology, one focused on the global inference and
more » ... lysis of the dynamic interactome. This burgeoning research area, which entails a shift from static to dynamic network analysis, promises to be a major step forward in our ability to model and reason about cellular function and behavior.
doi:10.1093/bib/bbp057 pmid:20061351 pmcid:PMC2810115 fatcat:xbj7ugs6nbed7guys2ie5z3efa