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Liposomes containing monosialoganglioside (G") or polyethylene glycol (PEG) lipid derivatives have prolonged circulation in the blood. This favours liposome extravasation to tumour sites. In this report it is shown that inclusion of G", PEGS,-DPPB or PEGmxrDPPE in liposomes containing biotin-DPPE signiticantly diminished the ability of vesicles to bind to streptavidin in vitro. Steric inhibition due to the bulky head group of these lipids was least for biotin-DPPE liposomes contaming C&i.doi:10.1016/0014-5793(93)80509-s pmid:8405439 fatcat:rdzv5unv6ffmfevmyfw7rqtpty