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Cancer kills 8 million annually worldwide. Although survival rates in prevalent cancers continue to increase, many cancers have no effective treatment, prompting the search for new and improved protocols. Immunotherapy is a new and exciting addition to the anti-cancer arsenal. The successful and accurate identification of aberrant host proteins acting as antigens for vaccination and immunotherapy is a key aspiration for both experimental and computational research. Here we describe key elementsdoi:10.1186/s12865-018-0248-x pmid:29544447 pmcid:PMC5856276 fatcat:dlh6qubumvfofjbnrxxwaafwie