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Akt/PKB enhances non-canonical Wnt signals by compartmentalizing β-Catenin
[article]
2017
bioRxiv
pre-print
Cellular proliferation is antagonistically regulated by canonical and non-canonical Wnt signals; their dysbalance triggers cancers. It is widely believed that the PI3-K>Akt pathway enhances canonical Wnt signals by affecting transcriptional activity and stability of beta-catenin. Here we demonstrate that the PI3-K>Akt pathway also enhances non-canonical Wnt signals by compartmentalizing beta-catenin. By phosphorylating the phosphoinositide(PI)-binding domain of a multimodular signal transducer,
doi:10.1101/149351
fatcat:bmleuzs37zh3tieldwa52cupye