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Problem statement: To report a case of severe injection site reaction at the site of an IM naltrexone injection in a 30 year old female. Approach: A 30 year old female, being treated with naltrexone extended-release injectable suspension for alcohol dependence, presented with a mass on her left upper gluteal area at the site of injection. The injectable naltrexone was discontinued, however the mass persisted. Upon referral to a general surgeon, it was determined that the mass was a hematoma ordoi:10.3844/ajptsp.2011.1.4 fatcat:jclqjpqofjgmdhbufjdgy6qnla