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Topical Citrullus colocynthis formulations are used as botanical treatment for painful diabetic neuropathy in Asian countries. This pilot study aimed to evaluate the safety and efficacy of topical formulation of Citrullus colocynthis fruit extract in treatment of painful diabetic neuropathy. The study was designed as a prospective interventional case series. Eight adults with clinical diagnosis of painful diabetic neuropathy confirmed by electrodiagnosis received oil-based topical formulationdoi:10.7897/2277-4343.056135 fatcat:5twba3abwfasbdxtqxd22kggyu