EDIBLE: experimental design and information calculations in phylogenetics

T. Massingham, N. Goldman
2000 Bioinformatics  
Although evolutionary inference from molecular sequences is a statistical problem, little attention has been paid to questions of experimental design. A computer program, EDIBLE, has been developed to perform likelihood calculations based on Markov process models of nucleotide substitution allied with phylogenetic trees, and from these to compute Fisher information measures under different experimental designs. These calculations can be used to answer questions of optimal experimental design in
more » ... molecular phylogenetics. Availability: Source code (ANSI C), executables and documentation for EDIBLE are available from http:// ng-dec1.gen.cam.ac.uk/ info/ index.html and 'downstream' Web pages.
doi:10.1093/bioinformatics/16.3.294 pmid:10869025 fatcat:q47r2hrxazdplmjtosclqdiive