The co-occurrence of multiple interacting medical and psychological disorders is extremely common. A signifi cant association between allergic disease (ADz -e.g., asthma, allergic rhinitis, allergic dermatitis) and depression has been reported. Objective: Path analysis models using cross-sectional data were constructed to evaluate the interrelationships among underlying co-occurring factors known to impact depression in young adults. Method: 885 college students (21.80 ± 3.22 years old)

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... d an online survey assessing current ADz, sleep quality, pain/discomfort, Body Mass Index, stress, substance use, Internet addiction, physical activity, social support and depression. Results: Our fi ndings suggest that ADz is only one of multiple factors modulating depression. Six factors had signifi cant direct effects (all p < .05) on depression: female gender, sleep quality, pain/ discomfort, stress, Internet addiction, and social support. ADz, Body Mass Index, and substance use had only indirect effects (all p < .05). Social support was associated with better sleep, less depression and less stress. Physical activity had no measurable effect on depression. Conclusions: This study is the fi rst attempt to evaluate the complex interrelations between ADz, depression and co-occurring factors. The complex interactions between variables in the model highlight the need to study these factors conjointly. Future longitudinal studies are needed to determine the temporal order and to validate causal pathways.