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Towards site-based protein functional annotations
2010
International Journal of Data Mining and Bioinformatics
The exact relationship between protein active centers and protein functions is unclear even after decades of intensive study. To improve the functional prediction ability based on the local protein structures, we proposed three different methods. 1) We used statistical model (known as Markov Random Field) to describe protein active region based on the structure motifs. 2) We developd a filter that considers the local environment around the active sites to remove the false positives. 3) we
doi:10.1504/ijdmb.2010.034200
pmid:20815142
pmcid:PMC2936724
fatcat:uyx5m4lvl5dnzgok4l72xkmivu