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Cell-type specific analysis of heterogeneous methylation signal using a Bayesian model-based approach
[article]
2019
bioRxiv
pre-print
Epigenome-wide association studies (EWASs) are often performed using DNA collected from heterogeneous cell samples yet there is often good reason to expect methylation variation in specific cell subtypes to be associated with disease. While statistical methods have been established to ascertaining cell-type fractions and to account for cell-type heterogeneity, methods to identify cell-type specific signals from heterogeneous samples in EWASs are lacking. We present a Bayesian model-based
doi:10.1101/682070
fatcat:xizn7fquijeefcpun5i2x4rttm