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has been reported that thrombin causes an endothelium-dependent relaxation of arteries4'15 and produces a contraction of veins that is only partially inhibited by endothelium removal.'4 Recently, thrombin has been shown to increase the intracellular inositol 1,4,5trisphosphate (InsP3) level and free [Ca'+] ([Ca2"]i) and to produce change in pHi in cultured smooth muscle cells from rat aorta.16'17 The aim of the present study was to characterize the electrophysiological effects of thrombin ondoi:10.1161/01.res.72.6.1317 pmid:8388325 fatcat:5d65fd3wufgofdb3cjpqa7upmy