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Therapeutic D2/3 receptor occupancies and response with low amisulpride blood concentrations in very late-onset schizophrenia-like psychosis (VLOSLP)
2017
International Journal of Geriatric Psychiatry
Objective: Antipsychotic drug sensitivity in very late-onset schizophrenia-like psychosis (VLOSLP) is well documented, but poorly understood. This study aimed to investigate blood drug concentration, D2/3 receptor occupancy, and outcome in VLOSLP during open amisulpride prescribing, and compare this with Alzheimer's disease (AD). Methods: Blood drug concentration, symptoms (suspiciousness, unusual thought content, hallucinations) and extrapyramidal side-effects (EPS), were serially assessed
doi:10.1002/gps.4758
pmid:28643852
fatcat:eocm6hlpabgxvckydh27spen3y