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Rabphilin-3A is a downstream target molecule of Rab3A small GTP-binding protein and implicated in Ca 2؉dependent neurotransmitter release. Here we have isolated a rabphilin-3A-interacting molecule from a human brain cDNA library by the yeast two-hybrid method and identified it to be ␣-actinin, known to cross-link actin filaments into a bundle. ␣-Actinin interacts with the N-terminal region of rabphilin-3A, with which GTP- Rab3A interacts, and this interaction stimulates the activity ofdoi:10.1074/jbc.271.50.31775 pmid:8943213 fatcat:323qclsu35cx3bgt5ujlcgk75e