525 After about the tenth week, when the ulcer improves, the serum calcium returns to normal, usually in about three weeks. If the animals survive much longer, during the remainiing weeks it continues normal or slightly higher. This is in striking contrast with the results obtained after intraperitoneal inoculation. In the latter experimenits the pulmonarylesioanis were matnly submiliary in character. With subcutaneous inoculation they were always much more extensive, and the weight of the

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... , generally, was over 80 grams (normal 8 grams). They consisted entirely of solid caseous masses, and such extensive dise'ase must inevitably interfere mechanically with pulmonary gas exchanige, and give rise to alterations in the acid-base batance. Evidence exists to suggest that acidosis results in anl increase in the serum calcium.'1 How far this mnay be operative during the later stages of my experiments, and thus mask the fall that miiight be expected, remuains for furlher iinvestigation.