Platelets Accumulation In The Liver : A novel Mechanism Of Thrombocytopenia In Chronic Hepatic C Patients

Ghada Galal, Mahmoud Abd-El-Fatah, Zeinab Al- Badawi, Yasser Mohamed
2018 Sohag Medical Journal  
and aim: Thrombocytopenia is a common complication of chronic liver diseases and is due to various causes.The effect of thrombocytopenia on liver damage and the exact mechanisms that lead to thrombocytopenia in chronic liver disease and cirrhosis are still unclear. As Platelets Derived Growth Factor ß (PDGF-ß) is released from platelets (PLTs) upon activation. We tried to identify PLTs and PDGFR-ß in the liver to shed some light on the pathophysiology of thrombocytopenia and liver fibrosis in chronic hepatic C patients.
doi:10.21608/smj.2018.40978 fatcat:ldylcr3k6fd5lk3qgjqwjodbgm