A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf
.
RTKN-1/Rhotekin shields endosome-associated F-actin from disassembly to ensure endocytic recycling
2021
Journal of Cell Biology
Cargo sorting and the subsequent membrane carrier formation require a properly organized endosomal actin network. To better understand the actin dynamics during endocytic recycling, we performed a genetic screen in C. elegans and identified RTKN-1/Rhotekin as a requisite to sustain endosome-associated actin integrity. Loss of RTKN-1 led to a prominent decrease in actin structures and basolateral recycling defects. Furthermore, we showed that the presence of RTKN-1 thwarts the actin disassembly
doi:10.1083/jcb.202007149
pmid:33844824
fatcat:py3gpwo6vbh7bgaqspabr5shoi