Integrating hypertension phenotype and genotype with hybrid non-negative matrix factorization

Yuan Luo, Chengsheng Mao, Yiben Yang, Fei Wang, Faraz S Ahmad, Donna Arnett, Marguerite R Irvin, Sanjiv J Shah, Jonathan Wren
2018 Bioinformatics  
Hypertension is a heterogeneous syndrome in need of improved subtyping using phenotypic and genetic measurements with the goal of identifying subtypes of patients who share similar pathophysiologic mechanisms and may respond more uniformly to targeted treatments. Existing machine learning approaches often face challenges in integrating phenotype and genotype information and presenting to clinicians an interpretable model. We aim to provide informed patient stratification based on phenotype and genotype features.
doi:10.1093/bioinformatics/bty804 pmid:30239588 pmcid:PMC6477985 fatcat:l2vc3nrma5fvvbfcqrsckxxhzi