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Integrating hypertension phenotype and genotype with hybrid non-negative matrix factorization
2018
Bioinformatics
Hypertension is a heterogeneous syndrome in need of improved subtyping using phenotypic and genetic measurements with the goal of identifying subtypes of patients who share similar pathophysiologic mechanisms and may respond more uniformly to targeted treatments. Existing machine learning approaches often face challenges in integrating phenotype and genotype information and presenting to clinicians an interpretable model. We aim to provide informed patient stratification based on phenotype and genotype features.
doi:10.1093/bioinformatics/bty804
pmid:30239588
pmcid:PMC6477985
fatcat:l2vc3nrma5fvvbfcqrsckxxhzi