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The Journal of Bone and Joint Surgery
W ear particles commonly used for experiments may carry adherent endotoxin on their surfaces, which may be responsible for the observed effects. In this study, we attached titanium plates to the tibiae of 20 rats. After osseointegration, endotoxincontaminated or uncontaminated high-densitypolyethylene (HDPE) particles were applied. Contaminated specimens showed a dramatic resorption of bone after seven days but new bone filled the site again at 21 days. Uncontaminated specimens showed nodoi:10.1302/0301-620x.84b5.11775 pmid:12188502 fatcat:nl6p6duy3jdavcr56slkdly6dm