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The nature of the structural changes induced by histone acetylation at the different levels of chromatin organization has been very elusive. At the histone level, it has been proposed on several occasions that acetylation may induce an ␣-helical conformation of their acetylated N-terminal domains (tails). In an attempt to provide experimental support for this hypothesis, we have purified and characterized the tail of histone H4 in its native and mono-, di-, tri-, and tetra-acetylated form. Thedoi:10.1074/jbc.m004998200 pmid:10938086 fatcat:vmfi6sqt5ve2ph6kdtsi3iuzma