Multi-conformers caused by conformational change of A-ring in the C18- and C19-N-dealkyl diterpenoid alkaloids

Xi-Xian Jian, Pei Tang, Xiao-Yu Liu, Ruo‑Bing Chao, Feng-Peng Wang
2023 figshare.com  
This paper describes a rare phenomenon of multi-conformers caused by conformational change of A-ring in the C18- and C19- N-dealkyl diterpenoid alkaloids. The possible reasons for the generation of multiple conformational isomers are complex, which could be affected by the substituents at C-1, C-3, C-13, C-14, and C-15, pH, solvents, the intramolecular hydrogen bond between 1α-OCH3/1α-OH and N-H groups, acid-base treatment, preparation methods, and work-up procedures.
doi:10.6084/m9.figshare.21877975.v1 fatcat:ls7wih2syjaijdrzxfla4s5zbq