Investigation of the value of miR-21 in the diagnosis of early stage HCC and its prognosis: a meta-analysis

S.R. Yan, Z.J. Liu, S. Yu, Y.X. Bao
2015 Genetics and Molecular Research  
The combined data for the prognostic meta-analysis (seven studies) suggested that miR-21 overexpression in HCC correlated with poor overall survival [HR = 1.19 (95%CI = 0.44-1.94)], and higher miR-21 expression was associated with tumor, node, metastases (TNM) stage [OR = 0.34 (95%CI = 0.13-0.91)]. We concluded that miR-21 might be complementary to alpha fetal protein in HCC diagnosis, and might serve as an attractive estimator of HCC. We also demonstrated that miR-21 overexpression was
more » ... ression was associated with HCC TNM stage and with poor survival. As our study was limited, additional prospective studies are needed to validate these results.
doi:10.4238/2015.september.28.9 pmid:26436398 fatcat:smxxmvwpvrg4ba2sh2pvn7yjvu