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Some cancer therapies damage DNA and cause mutations both in cancer and healthy cells of the patient. These therapy-induced mutations may underlie some of the long-term and late side effects of the treatment, such as mental disabilities, organ toxicities and secondary neoplasms. Currently we ignore the mutation pattern and burden caused by different cancer treatments. Here we identify mutational signatures, or footprints of six widely-used anti-cancer therapies with the study of whole-genomesdoi:10.1101/683268 fatcat:ksdeme64nnfjtlv7afitfcvl6q