A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf
.
Bringing microbiome-drug interaction research into the clinic
2019
EBioMedicine
Our understanding of the scope and clinical relevance of gut microbiota metabolism of drugs is limited to relatively few biotransformations targeting a subset of therapeutics. Translating microbiome research into the clinic requires, in part, a mechanistic and predictive understanding of microbiome-drug interactions. This review provides an overview of microbiota chemistry that shapes drug efficacy and toxicity. We discuss experimental and computational approaches that attempt to bridge the gap
doi:10.1016/j.ebiom.2019.05.009
pmid:31151933
pmcid:PMC6604038
fatcat:ycbjusyogng5hir53wszntkfmq