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Betaine Induced Autophagy to Protect Neurons Against Amyloid Beta in Alzheimer's Disease
[post]
2021
unpublished
Background: Alzheimer disease is a neurodegenerative disease, which is accompanied by the accumulation of amyloid beta and tau hyper phosphorylation. The objective of this study is to investigate amyloid-beta clearance through autophagy in HMC3 cells by betaine.Methods: In this study HMC3 cells were used. LC3, P62, p-AKT, p-MTOR, Beclin1, ATG 5, ATG 7, ATG 12 and beta-actin were studied by western blot. LC3 was studied by confocal microscopy. Neuroprotection and cell viability were assessed by
doi:10.21203/rs.3.rs-199905/v1
fatcat:bphaxirlozb25knhzexbgngvg4