Amyotrophic Lateral Sclerosis, due to its rapid evolution and the localization of functional disorders (upper limbs and speech), significantly reduces the effectiveness and use of disability aids. To develop and optimize the Pictocom system for communication and domotic control, we assessed all factors that could hinder its use, with questionnaires and a user-centered observation study during periods of system use. The results show that these factors may be related to the disease, such as the

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... ss of motor skills that makes difficult the interaction with a computer system. The personality of the patient and his psychological state influence the use or not of technical assistance. Finally, the physical and social environment of the patient are elements that can hinder the use of the system. Through the identification of these factors, improvement tracks are applied and demonstrate progress in the use of technical assistance.