Tissue spaces during development and regression of the decidual cell reaction in ovariectomized, steroid-treated mice

S. R. Milligan, C. Edwards
1990 Reproduction  
Changes in the extracellular and blood spaces of the uterus were assessed from the distribution volumes of 51Cr-EDTA and 51Cr-labelled red blood cells during the development and regression of the artificially induced decidual cell reaction in ovariectomized, steroid-treated mice. The normally high values for uterine extra cellular space (0\ m=. \ 35\ p=n-\ 0\ m=. \ 40\g=m\l/mg) fell to less than 0\m=.\20\g=m\l/mgin association with decidual growth. Uterine blood space increased from around
more » ... \02 \ g = m \ l / m g to 0\m=.\03\p=n-\0\m=.\05 \ g = m \ l / m g with decidual development. Induction of decidual regression by removal of s.c. progesterone implants caused a rapid decline in tissue blood volume to reach control values (0\ m=. \ 01\ p=n-\ 0\ m=. \ 02\g=m\l/mg) within 24 h and preceded any reduction in uterine weight. Uterine vascular permeability, as determined from the tissue accumulation of 125I \ x=req-\ labelled human serum albumin, fell with a similar time course. Tissue extracellular space returned to the higher control values within 48 h of initiating decidual regression.
doi:10.1530/jrf.0.0900191 pmid:2231541 fatcat:plx5imlduvfjdkp7mc5ip5khuu