Diabetes and Viral Infection

Moahmed Shaheen
2017 MOJ Public Health  
Type 1 diabetes (T1D) results from the autoantibody destruction of insulinproducing β-cells in the pancreas, particularly in early childhood. In addition to, immunological and genetic factors, the environmental factors such as viruses are believed to contribute to the type 1 diabete development. Various studies have detected certian viruses in the the pancreas of type 1 diabetic patients and found link between these viruses and T1D development using different techniques. Based on the
more » ... ical studies the enteroviruses, especially the coxsackievirus B, are the most common viruses found in type 1 diabetic patients. Virus infection might target β-cells and induce strong inflammation in the pancreatic β -cells, causing the initial step in autoimmunity induction. This review summarize the role of some viruses in the development of type 1 diabetes. Diabetes and Viral Infection 2/3 Copyright: ©2017 Shaheen 16. Oikarinen S, Martiskainen M, Tauriainen S, Huhtala H, Ilonen J, et al. (2011) Enterovirus RNA in blood is linked to the development of type 1 diabetes. Diabetes 60(1): 276-279. 17. Yeung WC, Rawlinson WD, Craig ME (2011) Enterovirus infection and type 1 diabetes mellitus: systematic review and meta-analysis of observational molecular studies. BMJ 342: d35. 18. Gallagher GR, Brehm MA, Finberg RW, Barton BA, Shultz LD, et al. Citation: Shaheen M (2017) Diabetes and Viral Infection. MOJ Public Health 6(2): 00165.
doi:10.15406/mojph.2017.06.00165 fatcat:m6vrc6glsne63dhtnyus5yff2q