A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is
Cell culture bioassay for vincristine sulfate in sera from mice, rats, dogs, and monkeys
When vincristine sulfate (VCR) was added to serum from mice, rats, dogs, or monkeys, as little as 0.01 vg/ml of VCR could be detected in a KB cell culture system. The bioassay was able to detect 88 to 100 percent of VCR added to the various serum samples. Mice and rats were treated intraperitoneally with 2.9 and 2.0 mg/kg respectively of VCR and bled at specific time intervals following drug administration. Dogs and monkeys were injected intravenously with 1.0 mg/kg of drug and bled atpmid:4980923 fatcat:tglauh2nhzbzlpwbyxidkhra4i