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Spherical calcium phosphate cement carriers were synthesized by water/oil emulsion. A 2 3 factorial design was employed in order to optimize the size and form of the microspheres. Stirring speed, liquid-to-powder ratio and cement paste-to-oil ratio were varied in two different levels and the response variable was the microsphere's sphericity. The results showed that cement's setting reaction was responsible for stabilizing the microspheres within the oil phase resulting in a low crystallinedoi:10.1590/1980-5373-mr-2016-0189 fatcat:aioxl774prb27pqri5cjwwrcte