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Primary immune thrombocytopenia (ITP) is a disorder that is characterized by immunemediated platelet destruction and impaired platelet production. We report the cases of four patients (patients 1-4) with ITP refractory to first-line treatment (glucocorticoids and immunoglobulin) who were treated with eltrombopag to achieve platelet counts of at least 50x109/l (threshold count-TC). Data were obtained from clinical histories and laboratory data. Evaluated parameters: previous treatments, plateletdoi:10.1136/ejhpharm-2012-000074.387 fatcat:7yfww7zhn5a6lhdeb3zupmhk64