GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation

Steve Poirier, Maya Mamarbachi, Wan-Ting Chen, Amy S. Lee, Gaetan Mayer
2015 Cell Reports  
Graphical Abstract Highlights d PCSK9 interacts with the ER-resident chaperone GRP94 d GRP94 is not an obligatory chaperone for PCSK9 d In the absence of GRP94, LDLR is more sensitive to PCSK9mediated degradation d GRP94 regulates LDLc levels by maintaining LDLR protein levels
doi:10.1016/j.celrep.2015.11.006 pmid:26628375 fatcat:cfqmfifawbgz7jpugk4dhi77hi