We developed a novel method for spatially-local selection of atlas-weights in multi-atlas segmentation that combines supervised learning on a training set and dynamic information in the form of local registration accuracy estimates (SuperDyn). Supervised learning was applied using a jackknife learning approach and the methods were evaluated using leave-N-out cross-validation. We applied our segmentation method to hippocampal segmentation in 1.5T and 3T MRI from two datasets: 69 healthy

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... ed subjects (aged 44-49) and 37 healthy and cognitively-impaired elderly subjects (aged 72-84). Mean Dice overlap scores (left hippocampus, right hippocampus) of (83.3, 83.2) and (85.1, 85.3) from the respective datasets were found to be significantly higher than those obtained via equally-weighted fusion, STAPLE, and dynamic fusion. In addition to global surface distance and volume metrics, we also investigated accuracy at a spatially-local scale using a surface-based segmentation performance assessment method (SurfSPA), which generates cohortspecific maps of segmentation accuracy quantified by inward or outward displacement relative to the manual segmentations. These measurements indicated greater agreement with manual segmentation and lower variability for the proposed segmentation method, as compared to equally-weighted fusion.