Abbreviations used: ASC, alanine-serine-cysteine system; BBB, blood-brain barrier; MeAIB, alpha methylaminoisobu tyric acid; BCH, 2-aminobicycIo-(2,2,I)heptane-2-carboxylic acid; Ch, choline; 3-MG, 3-0-methyl eH)-D-glucose. 585 by MeAIB. System ASC (alanine-serine-cysteine) ap peared to be of primary importance for the transport of these amino acids in isolated brain capillaries. The ap parent Km and V max values for L-alanine uptake by ASC transport, based on the Hofstee plot presentation,

more »

... 1.3 mM and 0. 975 nmol/ILI water content/min, respec tively. The results also indicate that the transport of MeAIB and 2-aminobicyc10(2,2,l)heptane-2-carboxylic acid (BCH) was limited to the sodium-dependent system A (alanine) and the sodium-independent system L (leu cine), respectively. Key Words: Blood-brain barrier Brain capillaries-Neutral amino acids-Transport system ASC.