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Safety and Immunogenicity of Mix-Match of Vaccines -Covishield and Covaxin – a Pilot Study [post]

Bhanu Prakash Reddy Attunuru, Podduturi Naveenchander Reddy, Sasikala Mitnala, Gujjarlapudi Deepika, Sadhana Yelamanchili Veturi, Duvvur Nageshwar Reddy
2022 unpublished

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This single-center prospective observational study was conducted to assess the safety and immunogenicity of combination vaccines AstraZeneca's ChAdOx1-nCov-19 (Covishield in India) and inactivated whole virion BBV152 (Covaxin). A total of 330 unvaccinated healthy volunteers were screened for SARS-COV2 seropositivity. RT PCR tests were conducted for seronegative volunteers (n =44). They were randomly assigned to four groups and given either same or mixed vaccines at an interval of 4 weeks
more » ... the two doses. Mix and match of vaccines did not evoke any adverse events. Combination of vaccines elicited similar immune responses in 4 groups. They were further studied dividing into homologous and heterologous vaccine groups. In Conclusion, Combination vaccines are safe and immunogenic and heterologous vaccines elicit better immunogenic response.
doi:10.21203/rs.3.rs-1210542/v2 fatcat:6bx5jufdxffqppxk4e4w6fof4a
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Bhanu Prakash Reddy Attunuru, Podduturi Naveenchander Reddy, Sasikala Mitnala, Gujjarlapudi Deepika, Sadhana Yelamanchili Veturi, Duvvur Nageshwar Reddy. "Safety and Immunogenicity of Mix-Match of Vaccines -Covishield and Covaxin – a Pilot Study." (2022)