The Relationship Between Lipid Profile and Outcomes of Pregnant Women with Gestational Diabetes Mellitus and Hypertensive Disorders: A Retrospective Study [post]

Yuan Li, Wenqing Chen, Xiaoqian Wang, Fengjuan Jiang, Xiaotian Chen
2020 unpublished
Background Dyslipidemia during pregnancy in women with gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) has been extensively studied in western countries. However, similar researches have rarely been conducted in Asia. The present study aimed to evaluate maternal lipid profile changes in relation to pregnancy complications and clinical outcomes.Methods The medical records of 668 pregnant women were retrospectively analyzed. Maternal fasting serum lipids were
more » ... rum lipids were assayed for total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), apolipoprotein A1 (Apo A1) and Apo B concentrations during the second trimesters. The atherogenic index of plasma (AIP) was calculated. The pregnancy complications included GDM and HDP. The clinical outcomes were collected by evaluating delivery mode, postpartum hemorrhage, macrosomia, birth weight, body length and neonatal Apgar score.Results Levels of TG and AIP were elevated while decreased TC and HDL-C was observed in women with GDM compared with that of the control group (p < 0.05). TG and AIP in HDP group were higher than in control group (p < 0.05). Significant differences were observed in postpartum hemorrhage, birth weight and body length between control group and women with GDM or HDP (p < 0.05). Compared with women with serum TG ≥ 2.5 mmol/L or TC ≥ 6.2 mmol/L, the incidence of GDM, cesarean section and macrosomia was lower in normal lipid group (p < 0.05). Spearman correlation analysis showed that the incidence of GDM was positively correlated with levels of TG (r = 0.226, p < 0.01) and AIP (r = 0.250, p < 0.01), while negative correlated with TC (r = -0.106, p < 0.01) and HDL-C (r = -0.190, p < 0.01). AIP was correlated positively with the incidence of HDP (r = 0.115, p = 0.043). According to the logistic regression analysis, each unit elevation in AIP increased the risk of GDM by 6.943 times (OR = 6.943, 95% CI: 1.761–27.374).Conclusions Lipid control, especially for women with GDM and HDP, might be a potential strategy for improving the pregnancy outcomes.
doi:10.21203/rs.3.rs-29209/v1 fatcat:hsajwt6wz5eztk7je2fnjgqyci