PPARγ Co-Activator-1α (PGC-1α) Reduces Amyloid-β Generation Through a PPARγ-Dependent Mechanism

Loukia Katsouri, Callum Parr, Nenad Bogdanovic, Michael Willem, Magdalena Sastre
2011 Journal of Alzheimer's Disease  
Supplementary Figure 1 . BACE1 KO reveals specificity of the antibody Ab5940 for BACE1 detection. BACE1 KO mice B6.129-Bace1tm1Pcw/J were obtained from Jackson ordered via Charles River, Germany. Representative Western blot is showing the BACE1 protein level in the mouse brain homogenates of 10 day old C57Bl6 mice or BACE1 −/− mice in the same background. On the left two normal mouse brains show specific BACE1 signals (65 kDa) whereas in the two Knock-out samples on the right no signal is
more » ... no signal is detected with the anti-BACE1 antibody Ab5940. Unspecific signal is detected by Ab5940 in the range below 50 kDa and above 100 kDa.
doi:10.3233/jad-2011-101356 pmid:21358044 fatcat:a2o7ezpqifalnnu32ielf6e6xa