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Focusing on the literature progress since 2002, the present review explores the highly significant role that multicomponent reactions (MCRs) have played as a very important tool for expedite synthesis of a vast number of organic molecules, but also, highlights the fact that many of such molecules are biologically active or at least have been submitted to any biological screen. The selected papers covered in this review must meet two mandatory requirements: (1) the reported products should bedoi:10.3390/molecules25030505 pmid:31991635 pmcid:PMC7038231 fatcat:qx4l7fwoffes3lc7pbbngomcri