Purpose: To report the efficacy of oral clopidogrel for treatment of chronic and recurrent central serous chorioretinopathy (CSC). Methods: This is a retrospective uncontrolled case series. Fourteen eyes in 14 patients with the clinical and angiographic findings of chronic and recurrent CSC were enrolled. Clinical data including bestcorrected visual acuity (BCVA), durations of symptoms, central retinal thickness (CRT) and macular volume measured on optical coherence tomography (OCT) were

more »

... ed at baseline. Oral clopidogrel 75 mg daily was administrated at least for 2 weeks until the serous detachment resolved or no satisfactory result was obtained. OCT was performed monthly until the end of follow-up in all patients. Fluorescein angiography was repeated during the follow-up period in nine patients. Results: There were eight eyes with chronic CSC and six with recurrent CSC. After clopidogrel treatment for mean 8.07 weeks (range, 2e24 weeks), the BCVA improved or stabilized in 12 of 14 eyes (85.7%) at the end of follow-up. Nine eyes (64.3%) attained a complete resolution of serous detachment, and four (28.6%) had improvement in subretinal fluid reabsorption on OCT. The CRT and macular volume were significantly decreased compared with baseline (234.14 AE 62.46 mm vs. 355.64 AE 108.05 mm, and 7.145 AE 0.618 mL vs. 7.916 AE 1.056 mL, respectively, p < 0.001). Seven eyes (77.78%) showed decreased numbers of leaking point as well as decreased intensity of dye leakage on repeated fluorescein angiography and one eye (11.11%) had a complete resolution in previous dye leakage. Five eyes received additional treatments (four eyes with laser photocoagulation and one eye with photodynamic therapy) during or after the clopidogrel therapy. In the subgroup of patients without additional treatments, the difference of CRT and macular volume was still statistically significant. Conclusion: Clopidogrel seems to be effective in the treatment of chronic CSC in this study. Its antithrombotic and anti-inflammatory actions may improve the choroidal congestion and facilitate the reabsorption of subretinal fluid.