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The physiological disposition of 5-fluorouracil in mice bearing solid L1210 lymphocytic leukemia
The physiological disposition of 5-fluorouracil (FU) and its metabolites, in particular 5-fluoro-2'-deoxyuridine 5'-monophosphate (FdUMP), has been studied in BDFj mice bearing 6-day solid L1210 lymphocytic leukemia up to 72 hr after a single i.v. dose of FU-2-14C, 200 mg/kg, 300 to 1000 juCi/kg. The drug persisted in all tissues, particularly in tumor, for hours after its elimination from blood. The anabolites of FU similarly persisted in both acid-soluble and acid-insoluble fractions ofpmid:4259631 fatcat:7e3hn6fwj5co7kscvf3wiju3m4