G93 The Outcome Of Prenatal Identification Of A Sex Chromosome Abnormality

A. Lucas-Herald, F. Cann, L. Crawford, C. Durajczyk, R. McGowan, S. Ahmed
2013 Archives of Disease in Childhood  
Abstracts A46 Arch Dis Child 2013;98(Suppl 1):A1-A117 Results Median weight in 6wk males (M6) and females (F6), 10wk males (M10) and females (F10) was 197g(range,142-230), 131g (121-135), 316g(274-365) and 206g(191-210) respectively. Median anogenital distance (AGD) in M6, F6, M10, F10 was 2.46cm (1.89-2.9), 1.17cm(1.04-1.19), 3.25cm(2.8-3.6) and 1.33cm(1.07-1.60). Median serum testosterone in M6 and M10 were 1.33ng/ml (0.23-5.45) and 3.36ng/ml(1. 75-8.26). 14 metabolites were identified in the
more » ... occipitofrontal cortex. FWHM range was within the optimal range at 12-38Hz. In M6, myo-inositol ratios showed a positive association with circulating testosterone (p = 0.04), and AGD was correlated with phosphocreatine (p = 0.033) and glutamate (p = 0.045). There was a difference between M6 and F6 in 3 metabolite ratios: phosphocholine (p = 0.014), lactate (p = 0.046) and NAA (p = 0.005). In addition, in males, there was an increase from 6wks to 10wks in 3 metabolite ratios: taurine (p = 0.025), myo-inositol (p = 0.012) and phosphocholine (p = 0.005). Conclusions MRS is a reliable tool for studying the brain in maturing rats and may be a useful tool for studying the link between longitudinal changes in sex steroids and brain development.
doi:10.1136/archdischild-2013-304107.105 fatcat:zcl33cw5cvetbfpg4rqqepy3we