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This study aimed to determine the effects of valsartan on the proliferation and migration of isolated rat vascular smooth muscle cells (VSMCs) and the expression of phospho-p42/44 mitogen-activated protein kinase (MAPK) promoted by angiotensin II (Ang II). VSMCs from the rat thoracic aorta were cultured by attachment-block culture. VSMCs' proliferation and migration were measured by MTT assay and migration chamber system, respectively. Phospho-p42/44 MAPK expression was determined by westerndoi:10.5897/ajb11.2410 fatcat:pfc6233ecbetphbi27mhmw7iue