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Cardiac electrophysiology is a mature discipline, with the first model of a cardiac cell action potential having been developed in 1962. Current models range from single ion channels, through very complex models of individual cardiac cells, to geometrically and anatomically detailed models of the electrical activity in whole ventricles. A critical issue for model developers is how to choose parameters that allow the model to faithfully reproduce observed physiological effects withoutdoi:10.1098/rsta.2010.0170 pmid:20643684 fatcat:2dvbzgnpdva7pia65nfsqcda5u