The primary purpose of this study was to assess predictors of success in e-learning courseware usability. E-learning courseware usability was treated as the dependent variable. The independent variables were age, gender, number of online courses taken, proficiency with using e-learning courseware, and college status. Multiple linear regression analysis was conducted to identify variables that best predict the usability of e-learning courseware. Research findings, recommendations, and implications for future research are discussed.