Salivary versus serum approaches in assessment of biochemical hyperandrogenemia

MohamedNabih El-Gharib, SaharMohey El-Din Hazaa
2014 Journal of Basic and Clinical Reproductive Sciences  
A B S T R A C T Background: Biochemically, hyperandrogenism is established by elevated circulating levels of free or total serum testosterone and an increased free androgen index. Approximately, 60-80% of women with polycystic ovarian syndrome (PCOS) demonstrate elevated circulating androgen levels. Aim: This prospective observational randomized study was to investigate the likelihood of using the salivary luteinizing hormone (LH), free testosterone (FT) and dehydroepiandrosterone sulfate
more » ... erone sulfate (DHEAS) levels instead of serum values in diagnosing biochemical hyperandrogenemia in women with PCOS. Subjects and Methods: This study was conducted on 75 women having PCOS in addition to 20 normal fertile women (control group). Venous blood and salivary samples were taken in the 3 rd day of the cycle to measure LH and FT and DHEAS levels. Results: Biochemical hyperandrogenemia prevails in 40% of women with PCOS. Salivary levels of LH, FT and DHEAS correlate with their corresponding serum values, with a higher sensitivity of salivary more than serum approach. Conclusion: Saliva provides a sensitive, simple, reliable, non-invasive and uncomplicated diagnostic approach for biochemical hyperandrogenemia.
doi:10.4103/2278-960x.129283 fatcat:oyjecugbyvc7fagtbsixxgs7ce